Ssa Antibody Reference Range

The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.

Ssa antibody reference range.

Ss a ro antibodies occur in patients with several different connective tissue. This has been termed antiphospholipid antibody syndrome. Lupus erythematosus le 40 60 of. Ss b la is composed of a 48 kd protein combined with rna species.

Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases. Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. 25 of cases both anti ro ssa and.

Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. The reference range of anti ro antibodies is negative. Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. Anti ss a and anti ss b are found in virtually all children with neonatal lupus.

Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies. Anti ro levels may be elevated in the following conditions. A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected.

Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. 60 70 of cases systemic lupus erythematosus sle. Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. The reference range of anti ro antibodies is negative.